InterPro domain: IPR042241

This superfamily covers families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome. The C-terminal domain is involved in the binding of gamma-tubulin, demonstrated by in vitro and deletion experiments with GCP4 (gamma-tubulin complex protein 4) [ 1 ].

1. Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation. Nat. Struct. Mol. Biol. 18, 915-9