InterPro domain: IPR042179
General Information
- Identifier IPR042179
- Description Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily
- Number of genes 247
- Gene duplication stats Loading...
Abstract
The 2-oxoglutarate dehydrogenase (OGDH) multienzyme complex is rate-limiting in the TCA cycle in many species, and is an essential nexus in the utilization of sugar and amino acids, funnelled via 2-oxoglutarate and oxidized to succinyl-CoA, process which releases CO2 and results in the reduction of NAD to NADH [ 1 ]. An alternative name for this complex is alpha-ketoglutarate dehydrogenase (KGD).
This superfamily represents the C terminus of the multifunctional 2-oxoglutarate metabolism enzyme KGD [ 2 ].
1. Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. J. Mol. Biol. 368, 639-51
2. Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem. Biol. 18, 1011-20