InterPro domain: IPR042108

General Information

  • Identifier IPR042108
  • Description GTPase HflX, N-terminal domain superfamily
  • Number of genes 221
  • Gene duplication stats Loading...

Abstract

This domain represents the N-terminal region of GTP-binding HflX-like proteins [ 1 , 2 ]. These proteins interact with the 50S ribosome and are GTPases, hydrolysing GTP/GDP/ATP/ADP [ 3 ]. The N-terminal region is necessary for stability of the whole protein, its structure is composed of four parallel beta-strand and four alpha-helices.


1. Properties of HflX, an enigmatic protein from Escherichia coli. J. Bacteriol. 191, 2307-14
2. Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. Biochemistry 48, 10793-802
3. E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. Biochem. Biophys. Res. Commun. 379, 201-5

Species distribution

Gene table