InterPro domain: IPR042103
General Information
- Identifier IPR042103
- Description Serine-tRNA synthetase, type1, N-terminal domain superfamily
- Number of genes 303
- Gene duplication stats Loading...
Abstract
This entry represents the N-terminal domain of Serine-tRNA synthetase, which consists of two helices in a long alpha-hairpin and corresponds to the tRNA binding domain. Serine-tRNA synthetase ( 6.1.1.11 ) exists as monomer and belongs to class IIa aminoacyl-tRNA synthetase [ 1 ].
The seryl-tRNA synthetase (SerRS) is a homodimeric enzyme that belongs to class II tRNA synthetases. SerRS catalyses the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis. Each monomer is comprised of two domains: an N-terminal tRNA-binding domain and a catalytic domain composed of seven-stranded anti-parallel beta-sheet [ 2 ].
1. Structure, function and evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code. J. Mol. Evol. 40, 519-30
2. Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes. Structure 21, 2078-86