InterPro domain: IPR042097

Aminopeptidase N from Escherichia coli is a broad specificity zinc exopeptidase belonging to aminopeptidase clan MA, family M1. The enzyme is composed of four domains: an N-terminal beta-domain, a catalytic domain, a middle beta-domain and a C-terminal alpha-domain [ 1 ].

This superfamily represents the N-terminal domain found in aminopeptidases and related proteins.

1. Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition. J. Biol. Chem. 281, 33664-76