InterPro domain: IPR042065
General Information
- Identifier IPR042065
- Description E3 ubiquitin-protein ligase ELL-like
- Number of genes 101
- Gene duplication stats Loading...
Abstract
This superfamily can be found in two different types of proteins, RNA polymerase II elongation factor ELL and E3 ubiquitin protein ligases UBR1 and UBR2. ELL functions as an E3 ubiquitin ligase and targets c-Myc for proteasomal degradation [ 1 ].
1. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nat Commun 7, 11057
Species distribution
Gene table
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