InterPro domain: IPR042011

These proteins show distinct phylogenetic origins from the family of ATX1 and ATX2. They are multi-domain proteins that consist of an N-terminal PWWP domain, a canonical PHD finger, a non-canonical extended PHD (ePHD) finger, and a C-terminal SET domain [ 1 , 2 ].

This entry represents the PHD finger of A. thaliana histone-lysine N-methyltransferase arabidopsis trithorax-like proteins ATX3, ATX4 and ATX5, which belong to the histone-lysine methyltransferase family.

1. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Nucleic Acids Res. 29, 4319-33
2. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC Evol. Biol. 12, 101