InterPro domain: IPR041897

This entry represents the MBL-fold found in integrator complex subunit 11 (INTS11 or Int11, also known as RC-68). Integrator (INT) is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing [ 1 , 2 ]. INTS11 is the endonuclease subunit for INT, responsible for the cleavage reaction at the 3' end of target RNAs [ 3 ]. INTS11 belongs to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions [ 4 ].

1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell 123, 265-76
2. The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Res. 25, 288-305
3. Integrator: surprisingly diverse functions in gene expression. Trends Biochem. Sci. 40, 257-64
4. An evolutionary classification of the metallo-beta-lactamase fold proteins. In Silico Biol. (Gedrukt) 1, 69-91