InterPro domain: IPR041888

ZNF598 is an E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC) [ 1 , 2 ]. It also associates with eukaryotic initiation factor 4E (eIF4E) homologous protein from mammalian (m4EHP) through binding to Grb10-interacting GYF protein 2 (GIGYF2). The m4EHP-GIGYF2 complex functions as a translational repressor and is essential for normal embryonic development of mammalian. ZNF598 harbours a C3HC4-type RING-HC finger at its N terminus [ 3 ].

This entry represents the RING-HC finger domain of ZNF598 from animals. This domain can also be found in Hel2 from yeasts [ 4 ].

1. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Mol. Cell 65, 743-750.e4
2. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol. Cell 65, 751-760.e4
3. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol. Cell. Biol. 32, 3585-93
4. Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control. Nat Commun 10, 563