InterPro domain: IPR041821

This entry represents the metallophosphatase domain of Drosophila melanogaster CG11883 and related proteins [ 1 ]. CG11883 is an uncharacterized Drosophila melanogaster UshA-like protein with two domains, an N-terminal metallophosphatase domain and a C-terminal nucleotidase domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases) [ 2 , 3 ].

1. Functional characterization of ecto-5'-nucleotidases and apyrases in Drosophila melanogaster. Insect Biochem. Mol. Biol. 41, 956-67
2. X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site. Nat. Struct. Biol. 6, 448-53
3. CDP-alcohol hydrolase, a very efficient activity of the 5'-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of Yersinia intermedia and Escherichia coli. J. Bacteriol. 190, 6153-61