InterPro domain: IPR041746
General Information
- Identifier IPR041746
- Description Lysine-sensitive aspartokinase catalytic domain
- Number of genes 145
- Gene duplication stats Loading...
Abstract
This entry includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional protein. It is involved in the overall regulation of the aspartate pathway and can be synergistically inhibited by S-adenosylmethionine [ 1 , 2 ]. Also included in this entry is an uncharacterized LysC-like AK found in Euryarchaeota and some bacteria. AK catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP.
1. The aspartic acid metabolic pathway, an exciting and essential pathway in plants. Amino Acids 30, 143-62
2. A novel organization of ACT domains in allosteric enzymes revealed by the crystal structure of Arabidopsis aspartate kinase. Plant Cell 18, 1681-92