InterPro domain: IPR041723

This entry represents the catalytic domain of CTP:phosphocholine cytidylyltransferase (CCT) [ 1 ]. It is also found in CTP:phosphoethanolamine cytidylyltransferase (ECT). ECT is composed of two tandem cytidylyltransferase (CT) domains; this entry corresponds the N-terminal CT domain, which is known to contribute to its catalytic activity [ 2 ]. CCT catalyzes the condensation of CTP and phosphocholine to form CDP-choline as the rate-limiting and regulatory step in the CDP-choline pathway. Similarly, ECT catalyzes the condensation of CTP and ethanolamine to form CDP-ethanolamine.

1. CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis. Prog. Lipid Res. 59, 147-71
2. Human CTP:phosphoethanolamine cytidylyltransferase: enzymatic properties and unequal catalytic roles of CTP-binding motifs in two cytidylyltransferase domains. Biochem. Biophys. Res. Commun. 449, 26-31