InterPro domain: IPR041677
General Information
- Identifier IPR041677
- Description DNA2/NAM7 helicase, helicase domain
- Number of genes 1925
- Gene duplication stats Loading...
- Associated GO terms GO:0004386
Abstract
This domain contains the ATP-binding region of DNA2. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Proteins containing this domain also include Nam7 and other helicases. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [ 1 , 2 ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway [ 3 ]. This domain is known as AAA_11 in Pfam.
1. Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism. Genetics 155, 1055-67
2. Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res. 40, 6774-86
3. RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent. Bioessays 40