InterPro domain: IPR041663

This HhH domain is a DNA-binding domain [ 1 ]. It can be found in bacterial checkpoint control protein DisA, NAD-dependent DNA ligase LigA, UvrABC system protein C [ 2 ] and in the ATP-dependent DNA helicase Hel308 (also known as HelQ) [ 3 ].

DNA integrity scanning protein (DisA) participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation [ 4 , 5 ].

1. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol. Cell 30, 167-78
2. The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system. Nucleic Acids Res. 30, 2492-500
3. Structure-function analysis of DNA helicase HELQ: A new diagnostic marker in ovarian cancer. Oncol Lett 12, 4439-4444
4. The Bacillus subtilis clpC operon encodes DNA repair and competence proteins. Microbiology (Reading, Engl.) 143 ( Pt 4), 1309-16
5. A checkpoint protein that scans the chromosome for damage at the start of sporulation in Bacillus subtilis. Cell 125, 679-90