InterPro domain: IPR041577

DNA polymerase and ribonuclease H (RNase H) activities allow reverse transcriptases to convert the single-stranded retroviral RNA genome into double-stranded DNA, which is integrated into the host chromosome during infection [ 1 ]. This domain can also be found in animal retrotransposon-like proteins [ 2 ].

This entry represents the RNase H-like domain found in a group of reverse transcriptases [ 3 , 3 , 4 ].

1. The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Structure 12, 819-29
2. Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat. Genet.
3. Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid. Nucleic Acids Res. 21, 389-96
4. Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nat. Struct. Mol. Biol. 40, 243-8