InterPro domain: IPR041546

This entry represents the alpha helical AAA+ lid domain that is found to the C terminus of AAA domains.

Proteins containing this domain include ClpA/B [ 1 , 2 ]. These proteins are thought to protect cells from stress by controlling the aggregation and denaturation of vital cellular structures. They vary in size, but share a domain which contains an ATP-binding site.

1. Hsp104 is a highly conserved protein with two essential nucleotide-binding sites. Nature 353, 270-3
2. Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes. Proc. Natl. Acad. Sci. U.S.A. 87, 3513-7