InterPro domain: IPR041433

General Information

  • Identifier IPR041433
  • Description 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
  • Number of genes 193
  • Gene duplication stats Loading...

Abstract

This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the centre capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base [ 1 ]. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6) [ 2 ].


1. Structural basis for dynamic regulation of the human 26S proteasome. Proc. Natl. Acad. Sci. U.S.A. 113, 12991-12996
2. Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc. Natl. Acad. Sci. U.S.A. 113, 2642-7

Species distribution

Gene table