InterPro domain: IPR041330

This domain can be found at the C terminus of the human KIN17 protein and its homologues. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution [ 1 ].

1. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. J. Mol. Biol. 364, 764-76