InterPro domain: IPR041221

This is the C-terminal domain of anaphase-promoting complex subunit 1 (APC1)[ 1 ].

Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [ 2 , 3 ]. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex [ 4 ].

1. Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature 522, 450-454
2. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene 262, 51-9
3. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 7, 644-56
4. Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J. Virol. 82, 529-37