InterPro domain: IPR041195

This entry represents the N-terminal triple barrel domain found in Rnh202 (also known as ribonuclease H2 subunit B), a non catalytic subunit of ribonuclease H2. RNases H2 cleaves RNA sequences that are part of RNA/DNA hybrids or that are incorporated into DNA. It prevents genomic instability and the accumulation of aberrant nucleic acid [ 1 , 2 ].

1. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res. 32, 407-14
2. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects. J. Biol. Chem. 286, 10540-50