InterPro domain: IPR041123

Chromosome region maintenance 1 or exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats [ 1 ] that are structurally similar to HEAT repeats, but share little sequence similarity with them [ 2 ]. N-terminal, C-terminal and central repeats show slightly different structural arrangements, with N- and C- termini repeats interacting with each other. This entry represents the central repeats of CRM1.

1. Structural basis for cooperativity of CRM1 export complex formation. Proc. Natl. Acad. Sci. U.S.A. 110, 960-5
2. Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol. Cell 16, 761-75