InterPro domain: IPR041101

The F-box protein transport inhibitor response 1 (TIR1) is a receptor for auxin, triggering an auxin-enhanced and ubiquitin-mediated degradation of substrates [ 1 ]. The targets are recruited via interaction with the leucine-rich repeat region of the protein. This entry represents a specific unit of the LRR region, including an insertion of one short alpha-helix in the loop between the beta-strand and the following helix. It shares some sequence homology with a unit with similar structure of coronatine-insensitive protein 1 [ 2 ].

1. Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc. Natl. Acad. Sci. U.S.A. 105, 5632-7
2. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature 468, 400-5