InterPro domain: IPR041054

This is the N-terminal domain of Rrp40, an non-catalytic component of the RNA exosome complex from budding yeasts. The RNA exosome complex is responsible for degrading RNA molecules in the 3' to 5' direction. Rrp40 is a 'cap' protein and binds the RNase PH barrel on the opposite side from the S1/KH ring. The N-terminal domain of Rrp44 forms a long beta-hairpin that is wedged in between Rrp41-Rrp42 and approaches the N terminus of the cap protein Rrp4 [ 1 ].

1. Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex. Nature 495, 70-5