InterPro domain: IPR041024
General Information
- Identifier IPR041024
- Description Mcm6, C-terminal winged-helix domain
- Number of genes 123
- Gene duplication stats Loading...
Abstract
The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments [ 1 ]. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD [ 2 ].
1. Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J. Biol. Chem. 285, 12469-73