InterPro domain: IPR041006
General Information
- Identifier IPR041006
- Description Morc, S5 domain 2-like
- Number of genes 644
- Gene duplication stats Loading...
Abstract
This domain is found in MORC proteins in eukaryotes and possesses a structure similar to the second domain of ribosomal S5 proteins. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing [ 1 ]. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.
1. Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis. PLoS Genet. 12, e1006026