InterPro domain: IPR040870

General Information

  • Identifier IPR040870
  • Description HEN1, double-stranded RNA binding domain 2
  • Number of genes 132
  • Gene duplication stats Loading...

Abstract

This domain is found in HEN1 proteins from Arabidopsis. Structural characterization revealed that small RNA substrate binds to two double-stranded RNA (dsRNA)-specific binding domains, dsRBD1 and dsRBD2. This entry relates to dsRBD2 which together with dsRBD1 forms a strong grip on the duplex region of the small RNA substrate, and these interactions help position the other duplex terminus towards the MTase domain ( IPR025714 ) [ 1 ].


1. Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature 461, 823-7

Species distribution

Gene table