InterPro domain: IPR040848

This entry represents the alpha helical AAA+ lid domain that is found to the C terminus of AAA domains. This lid domain is found in midasin proteins.

Midasin (MDN1, REA1) is a is a member of the AAA(+) family of ATPases. It is a nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits [ 1 , 2 , 3 , 4 ].

1. Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits. J. Biol. Chem. 279, 55411-8
2. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol. Cell 15, 295-301
3. Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138, 911-22
4. The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol. Cell 38, 712-21