InterPro domain: IPR040707

This is the N-terminal domain found in formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as phosphoribosylformylglycinamidine synthase ( 6.3.5.3 ), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway [ 1 ].

1. Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis. PLoS ONE 8, e77781