InterPro domain: IPR040662

General Information

  • Identifier IPR040662
  • Description Transcription factor Tfb2, C-terminal domain
  • Number of genes 120
  • Gene duplication stats Loading...

Abstract

This is the C-terminal domain of transcription factor Tfb2 present in Saccharomyces cerevisiae. Tfb2 is known as p52 in humans. The interaction between p8-Tfb5 and p52-Tfb2 has a key role in the maintenance of the transcription factor TFIIH architecture and TFIIHs function in nucleotide-excision repair (NER) pathway. The C-terminal domain of Tfb2 is thought to have a crucial role in DNA repair [ 1 ].


1. Structural basis for group A trichothiodystrophy. Nat. Struct. Mol. Biol. 15, 980-4

Species distribution

Gene table