InterPro domain: IPR040485

Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats [ 1 ] that are structurally similar to HEAT repeats, but share little sequence similarity with them [ 2 ]. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other.

1. Structural basis for cooperativity of CRM1 export complex formation. Proc. Natl. Acad. Sci. U.S.A. 110, 960-5
2. Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol. Cell 16, 761-75