InterPro domain: IPR040464

General Information

  • Identifier IPR040464
  • Description Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain
  • Number of genes 631
  • Gene duplication stats Loading...

Abstract

This entry represents the ATP-grasp domain. Proteins containing this domain include several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [ 1 ].


1. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J. Biol. Chem. 271, 11904-10

Species distribution

Gene table

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