InterPro domain: IPR040464
General Information
- Identifier IPR040464
- Description Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain
- Number of genes 631
- Gene duplication stats Loading...
Abstract
This entry represents the ATP-grasp domain. Proteins containing this domain include several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [ 1 ].
1. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J. Biol. Chem. 271, 11904-10
Species distribution
Gene table
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