InterPro domain: IPR040463

The mammalian B-cell receptor-associated proteins of 29 and 31kDa (BAP29 and BAP31) are integral membrane proteins with a role in endoplasmic reticulum (ER) quality control and sorting [ 1 , 2 , 3 ]. BAP31 is also involved in apoptosis [ 4 ]. Saccharomyces cerevisiae possesses three homologues of BAP31 known as Yet1, Yet2, and Yet3 [ 5 ].

These proteins are predicted to have three transmembrane segments with a cytoplasmic, coiled-coil C-terminal domain [ 6 ]. This entry represents the transmembrane region.

1. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J. Cell Biol. 139, 1397-410
2. Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules. J. Immunol. 177, 6172-81
3. Bap29/31 influences the intracellular traffic of MHC class I molecules. J. Immunol. 172, 7548-55
4. Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J. 30, 556-68
5. Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. J. Biol. Chem. 285, 18252-61