InterPro domain: IPR040461

Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [ 1 , 2 , 3 ].

The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein [ 4 ]. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 [ 5 ].

1. The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. Cell 94, 375-86
2. A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination. EMBO J. 20, 3871-81
3. Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. J. Biol. Chem. 279, 35263-72
4. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem. Biophys. Res. Commun. 239, 176-81