InterPro domain: IPR040451

The glycosyl hydrolase family 81 comprises beta-1,3-glucanases. Within the Aspergillus fumigatus protein Q9UVV0 two perfectly conserved Glu residues (E550 or E554) have been proposed as putative nucleophiles of the active site of the Engl1 endoglucanase, while the proton donor would be D475. The endo-beta-1,3-glucanase activity is essential for efficient spore release [ 1 ]. This entry represents the N-terminal beta sandwich domain.

1. {beta}-glucanase Eng2 is required for ascus wall endolysis after sporulation in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell 8, 1278-86