InterPro domain: IPR040424
General Information
- Identifier IPR040424
- Description Survival motor neuron-like protein 1
- Number of genes 101
- Gene duplication stats Loading...
Abstract
A survival motor neuron (SMN) orthologue has been identified and characterized in Schizosaccharomyces pombe [ 1 , 2 ]. As its mammalian counterpart, Smn plays a crucial role in the generation of the pre-mRNA splicing machinery and in mRNA biogenesis by interacting with spliceosomal snRNPs [ 3 , 4 ]. Interestingly, Smn is not present in Saccharomyces cerevisiae. Orthologues of this gene in fungi seem to be present predominately in filamentous fungi [ 4 ].
1. Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein. Hum. Mol. Genet. 9, 675-84
2. The survival motor neuron protein of Schizosacharomyces pombe. Conservation of survival motor neuron interaction domains in divergent organisms. J. Biol. Chem. 275, 23841-6
3. Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene. EMBO J. 29, 1817-29
4. Fungal Smn and Spf30 homologues are mainly present in filamentous fungi and genomes with many introns: implications for spinal muscular atrophy. Gene 491, 135-41