InterPro domain: IPR040366
General Information
- Identifier IPR040366
- Description Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14
- Number of genes 207
- Gene duplication stats Loading...
- Associated GO terms GO:0008143 GO:1900364 GO:0043488
Abstract
Budding yeast Nab2 is a nuclear polyadenylated RNA-binding protein that contains seven CCCH-type zinc fingers and an RGG box [ 1 ]. It is required for nuclear mRNA export and poly(A) tail length control [ 2 , 3 ]. The tertiary structure has been solved and the protein is all helical ( 3LCN ). Its animal homologue, known as ZC3H14, has been shown to control poly(A) tail length in neuronal cells [ 4 ].
1. NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability. Mol. Cell. Biol. 13, 2730-41
2. Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J. Biol. Chem. 277, 7752-60
3. Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export. EMBO J. 21, 1800-10
4. A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. RNA 20, 681-8