InterPro domain: IPR040357

This entry includes Vma22 from yeasts and CCDC115 from animals. Vma22 is an endoplasmic reticulum-associated protein required for V-ATPase activity [ 1 ]. CCDC115 is an accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis [ 2 ].

1. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. J. Biol. Chem. 270, 22329-36
2. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. Elife 6