InterPro domain: IPR040319

This entry represents a group of zinc finger containing proteins from plants and green algae, including LSD and LOL proteins. LSD (LESION SIMULATING DISEASE1) functions as a negative programmed cell death regulator that integrates various signaling pathways in response to both biotic and abiotic stresses [ 1 ]. It regulates crosstalk between light acclimation and immunity in Arabidopsis [ 2 ]. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death [ 3 ]. The rice LOL2 is involved in rice growth and disease resistance [ 4 ].

1. The Role of Programmed Cell Death Regulator LSD1 in Nematode-Induced Syncytium Formation. Front Plant Sci 9, 314
2. Chloroplast signaling and LESION SIMULATING DISEASE1 regulate crosstalk between light acclimation and immunity in Arabidopsis. Plant Cell 20, 2339-56
3. Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins. Proc. Natl. Acad. Sci. U.S.A. 100, 6831-6
4. The rice OsLOL2 gene encodes a zinc finger protein involved in rice growth and disease resistance. Mol. Genet. Genomics 278, 85-94