InterPro domain: IPR040315

This entry contains proteins with a BING4-like, C-terminal domain. WD repeat-containing protein 46 (WDR46) is a component of the nuclear scaffold, which is an insoluble structure that contributes to the inner nuclear organization. WDR46 is a fundamental scaffold component of the nucleolar structure, binding nucleolin and DDX21 [ 1 ]. Also in this family is U3 small nucleolar RNA-associated protein 7 (UTP7) from baker's yeast, which is involved in nucleolar processing of pre-18S ribosomal RNA [ 2 ].

1. Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21. Genes Cells 18, 780-97
2. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417, 967-70