InterPro domain: IPR040309
General Information
- Identifier IPR040309
- Description H/ACA ribonucleoprotein complex non-core subunit Naf1
- Number of genes 149
- Gene duplication stats Loading...
- Associated GO terms GO:0003723 GO:0000493 GO:0042254 GO:0005732
Abstract
Naf1 is an RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex, disappearing during maturation of the complex and being replaced by Gar1 to yield mature H/ACA snoRNPs complex. The core domain of Naf1 is homologous to the core domain of Gar1, suggesting that they share a common Cbf5 binding surface [ 1 ].
1. The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. J. Mol. Biol. 371, 1338-53
Species distribution
Gene table
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