InterPro domain: IPR040221

Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 [ 1 ]. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorilation by AKT leads to loss of its association with Myc [ 2 ]. This interaction affects Myc-dependent apoptosis and transformation [ 3 , 4 , 5 ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [ 5 ].

Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc [ 6 ]. JPO2 overexpression induces metastasis in medulloblastoma [ 6 ]. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [ 7 , 8 ].

JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter [ 9 ]. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways [ 10 ].

This entry includes CDCA7 and CDA7L.

1. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim. Biophys. Acta 1759, 60-8
2. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol. Cell. Biol. 33, 498-513
3. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. J. Biol. Chem. 276, 48276-84
4. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 65, 5607-19
5. Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. J. Exp. Med. 211, 2411-23
6. JPO2/CDCA7L and LEDGF/p75 are novel mediators of PI3K/AKT signalling and aggressive phenotypes in medulloblastoma. Cancer Res. 289, 12494-506
7. Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. J. Cell. Sci. 103, 10923-8
8. Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin. J. Biol. Chem. 119, 2563-71
9. R1, a novel repressor of the human monoamine oxidase A. J. Biol. Chem. 280, 11552-9
10. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc. Natl. Acad. Sci. U.S.A.