InterPro domain: IPR040203
General Information
- Identifier IPR040203
- Description DNA replication regulator Sld2
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0006270
Abstract
This entry includes Sld2 from budding yeasts and Drc1 from fission yeasts. Sld2 is required for the initiation of DNA replication. Its association with DNA is required for the assembly of the Cdc45-Mcm2-7-GINS (CMG) replicative helicase complex in S phase [ 1 ]. Sld2 can be regulated by S-Cdk-dependent phosphorylation [ 2 ]. Similarly, Drc1 is regulated by Cdk phosphorylation and is required for DNA replication [ 3 ]. Drc1 interacts with Cut5 and plays a role in the loading of Cut5 onto origins of replication [ 4 ].
1. The replication initiation protein Sld2 regulates helicase assembly. J. Biol. Chem. 289, 1948-59
2. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415, 651-5
3. CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr. Biol. 12, 599-605
4. CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol. Biol. Cell 22, 2620-33