InterPro domain: IPR040184

Minichromosome maintenance protein 10 (Mcm10) is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha [ 1 ]. It is required for DNA synthesis and for entry into or completion of S phase. It is associated with the DNA polymerase-alpha (pol-alpha) primase complex throughout the cell cycle, and is a nuclear chaperone for Cdc17, which is otherwise rapidly degraded [ 2 ]. It is also required for maintenance of transcriptional silencing [ 3 ].

1. Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol. Cell 16, 173-85
2. A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast. J. Biol. Chem. 281, 18414-25
3. Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae. Genetics 171, 503-15