InterPro domain: IPR040122

General Information

  • Identifier IPR040122
  • Description Importin beta family
  • Number of genes 1280
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006606  

Abstract

This family consists of the karyopherins importin-beta and transportin. Importin subunit beta-1 forms a complex with an importin alpha subunit. The importin complex is required for nuclear protein import. Importins bind to NLSs in their protein cargos to transport them through the nuclear pore into the nucleus [ 1 ].

Transportin-1 and -2 also function in nuclear import [ 2 ]. Transportin-1 was first identified as the import factor for the heterogeneous ribonucleoprotein A1 (hnRNP A1) [ 3 ].


1. Nuclear localization signals for four distinct karyopherin-β nuclear import systems. Biochem. J. 468, 353-62
2. Transportin-1 and Transportin-2: protein nuclear import and beyond. FEBS Lett. 588, 1857-68
3. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J. Cell Biol. 138, 1181-92

Species distribution

Gene table