InterPro domain: IPR040115

General Information

  • Identifier IPR040115
  • Description Lunapark family
  • Number of genes 211
  • Gene duplication stats Loading...
  • Associated GO terms GO:0071786  

Abstract

Lunapark (Lnp) is an endoplasmic reticulum (ER)-shaping membrane protein named after its conserved L-N-P-A-R-K peptide motif. It may serve as a curvature-stabilizing protein within tubular three-way junctions of the ER [ 1 ]. Mutations in the Lnp gene has been linked to neurodevelopmental syndrome [ 2 ].


1. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 112, 418-23
2. Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Am. J. Hum. Genet. 103, 296-304

Species distribution

Gene table