InterPro domain: IPR040107

General Information

  • Identifier IPR040107
  • Description U4/U6.U5 small nuclear ribonucleoprotein component Snu23
  • Number of genes 132
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005681   GO:0000398  

Abstract

Pre-mRNA splicing is an important step in eukaryotic gene expression. Yeasts and humans share a common set of core spliceosomal proteins that are evolutionarily conserved such as B complex proteins Snu23 (known as ZMAT2 in humans), Prp38 and MFAP1 [ 1 , 2 ]. This entry represents Snu23. Its structure has been revealed [ 3 , 3 ].


1. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc. Natl. Acad. Sci. U.S.A. 96, 7226-31
2. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170, 701-713.e11
3. Structure of a pre-catalytic spliceosome. Nature 546, 617-621

Species distribution

Gene table