InterPro domain: IPR040092

TBRG1, also known as NIAM (nuclear interactor of ARF and Mdm2), is a p53 activator that causes a G1 phase cell cycle arrest, and collaborates with ARF in an additive fashion to suppress proliferation [ 1 ]. NIAM has also been shown to associate with chromatin-associated protein and bind to Tip60 [ 2 ].

1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J. Biol. Chem. 282, 1322-33
2. Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53. Cell Cycle 13, 1288-98