InterPro domain: IPR040053
General Information
- Identifier IPR040053
- Description Josephin-1/2
- Number of genes 118
- Gene duplication stats Loading...
- Associated GO terms GO:0004843
Abstract
Josephin proteins 1 and 2 are deubiquitinating enzymes (DUBs; peptidase family C86) that contain the Josephin domain, characteristic of the MJD family of DUBs. Josephin-1 (JOSD1) releases 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains, provided it is monoubiquitinated itself. Josephin-2 (JOSD2) releases 'Lys-63'-linked poly-ubiquitin chains, but does not require ubiquitination to be active. Ubiquitinated JOSD1 is localized to the plasma membrane, whereas JOSD2 is cytoplasmic [ 1 ]. Josephin-like proteins are also found in Arabidopsis thaliana and Drosophila melanogaster.
1. JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. J. Biol. Chem. 288, 17145-55