InterPro domain: IPR040052

This entry includes proteins with a G-patch domain and a RNA recognition motif domain, including mammalian splicing factor 45 (SPF45; also known as RNA-binding motif protein 17 or RBM17) and plant DNA-damage-repair/toleration protein DRT111 (also known as RSN2). SPF45 is an mRNA spliceosomal protein that is required for alternative splicing and the utilization of cryptic splice sites. The beta-110 mutation in the haemoglobin beta causes activation of a cryptic 3' splice site that is the cause of human beta-thalassemia (sickle-cell anemia) [ 1 ]. DRT111 is also required for pre-mRNA splicing, particularly the mRNA for receptor-like kinase SNC4, which activates the defence response to microbial pathogens in plants [ 2 ].

1. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Cell 109, 285-96
2. Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant 7, 1766-75