InterPro domain: IPR040044

SRR1 are signalling proteins thought to be involved in regulating the circadian clock input pathway, which is required for normal oscillator function. In Arabidopsis thaliana it regulates the expression of clock-regulated genes such as CCA1 and TOC1. It is also involved in both the phytochrome B (PHYB) and PHYB-independent signaling pathways [ 1 ]. The mouse homologue of the plant circadian-regulating protein SRR1 plays roles in heme-regulated circadian rhythms and cell proliferation [ 2 ].

The yeast SRR1-like protein Ber1 is involved in microtubule stability [ 3 ].

This entry includes the plant Sensitivity To Red Light Reduced proteins (SRR1), yeast SRR1-like protein Ber1 and mammalian homologue SRR1 domain containing (SRRD) protein.

1. The Arabidopsis SRR1 gene mediates phyB signaling and is required for normal circadian clock function. Genes Dev. 17, 256-68
2. The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms. Arch. Biochem. Biophys. 631, 19-29
3. The evolutionary conserved BER1 gene is involved in microtubule stability in yeast. Curr. Genet. 53, 107-15